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Table of Contents
ORIGINAL ARTICLE
Year : 2012  |  Volume : 6  |  Issue : 2  |  Page : 71-74

Ethnic differences in colon and rectal cancer incidence in Nigeria: A case of dietary determinants?


Department of Surgery, College of Medicine, University of Ibadan, Nigeria

Date of Web Publication7-Mar-2013

Correspondence Address:
David O Irabor
Surgery Department, University College Hospital Ibadan, PMB 5116 Ibadan, Oyo State
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0331-3131.108123

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   Abstract 

Background: Colorectal cancer has for a long time occurred at lower rates in the native Africans than in the Caucasians. The reasons adduced include lack of pre-malignant conditions like polyps and ulcerative colitis and mostly to the high fiber, low animal protein diet that Africans consume. Nigeria has a low colorectal cancer incidence and within this milieu the incidence between the various ethnic tribes also varies with some particular tribes exhibiting negligible incidence rates. If moving from a location of low colorectal cancer incidence to one of high colorectal cancer incidence predisposes one to develop the disease, could not the converse apply and those with a predisposition to developing the disease experience some protection when they live or interact with those with negligible predisposition?
Aim: This study is aimed at giving an impetus to research within the ethnic regions of Nigeria with the lowest colorectal cancer incidence in a bid to unravel the cancer preventive factors either in their diet or environment for the good of those from the Western world.
Materials and Methods: This is a retrospective study utilizing the records of patients who had surgery for colorectal cancer at the University College Hospital Ibadan, Nigeria, between 2002 and 2010 with particular attention to the ethnic groups to which they belong.
Results: From 2002 to 2010, a total of 500 colorectal cancer cases were operated on at the University College Hospital (UCH) Ibadan, giving an annual rate of about 63 patients. Out of these patients, 73% were Yoruba (the dominant and indigenous ethnic group in Ibadan), 13.5% were Ibo, and 12.9% were from Bendel, while Hausa, cross-river and rivers made up the remaining 1.5%, 1.8% and 0.5%, respectively.
Conclusion: There is no doubt that while Nigeria as a whole is regarded as a country with low colorectal cancer incidence, there are regions within the country where the incidence is almost negligible. I believe further research into these areas may improve our understanding of chemo-preventive factors, which can only augur well for the global measures in the prevention and management of colorectal cancer.

Keywords: Colon cancer, low incidence in riverine Nigerians


How to cite this article:
Irabor DO. Ethnic differences in colon and rectal cancer incidence in Nigeria: A case of dietary determinants?. Ann Nigerian Med 2012;6:71-4

How to cite this URL:
Irabor DO. Ethnic differences in colon and rectal cancer incidence in Nigeria: A case of dietary determinants?. Ann Nigerian Med [serial online] 2012 [cited 2020 Jan 18];6:71-4. Available from: http://www.anmjournal.com/text.asp?2012/6/2/71/108123


   Introduction Top


Colon and rectal carcinoma are not common in native Nigerians when compared to the incidence of this disease in the United States (US) and the United Kingdom (UK). Nevertheless studies in Nigeria have shown increased rates of this disease over the last 20 years. [1],[2] This increase has been hinged on change in the hitherto rural lifestyle and diet to the more urban and Caucasian type. Over the last 20 years, colorectal cancer (CRC) in Nigeria was not within the top 10 cancers; recently it has become the fourth most common cancer in Nigeria. [2] Yet the rates seen in Nigeria and indeed in Africa in general are not up to a 30 th of what is seen in the western world. Reasons adduced include the native African diet and lack of pre-malignant colorectal lesions.

Within this Nigerian microcosm of CRC cases, it has been observed that a difference in incidence also exists between the various ethnic groups in the country. We do know that foodstuff and diet are peculiar to the various ethnic groups in this country and exposure to and adoption of western lifestyle is not the same in these ethnic groups. If indeed the diet of a certain ethnic group prevents the development of CRC then it is worthwhile to study this in detail. Migration studies have shown that people who migrate from a place of low CRC incidence to one of high incidence ultimately develop the disease or their offspring do. Thus why not conversely? If it can be highlighted that certain geographical locations have a very low incidence because of the diet consumed there then it should be possible to reduce the incidence of CRC in patients with a high risk if they migrate to these places with low incidence.

The rationale for this study is to highlight such a pattern and lay the grounds for a prospective study to see the effect e.g., high risk patients with colonic polyps spending 3 months in such a site, eating the native food and afterward comparing the pre- and post-visit colonoscopy appearances.

The UCH in Ibadan, a tertiary care institution, is located in the largest city in West Africa and is adjudged to be a place that is cosmopolitan enough to represent the diverse variety of ethnic groups in the country as a whole. The hospital serves the whole of Ibadan (population of 2.5 million) and its environs and also receives referrals from all over Nigeria.


   Materials and Methods Top


This is a retrospective study utilizing the records of patients who had surgery for CRC at the UCH Ibadan, Nigeria, between 2002 and 2010 with particular attention to the ethnic groups to which they belong.


   Results Top


From 2002 to 2010, a total of 500 CRC cases were operated on at the UCH Ibadan, giving an annual rate of about 63 patients. Colon cancer cases were 244 (48.8%), rectosigmoid locations were 34 (6.8%) and rectal cancer cases were 222 (44.4%).

Out of these patients, 73% were Yoruba (the dominant and indigenous ethnic group in Ibadan), 13.5% were Ibo, 12.9% were from Bendel, while Hausa, cross-river and rivers made up the remaining 1.5%, 1.8% and 0.5%, respectively [Figure 1].
Figure 1: Proportion of ethnic groups with colorectal carcinoma

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   Discussion Top


The UCH Ibadan located in the capital of the old western state of Nigeria, and which is also the first and the largest teaching hospital in Nigeria, caters to the highest number of CRC cases seen in Nigeria. The old western state was the enclave of the Yoruba race; even though the state has been split into 5 different states, the UCH Ibadan still serves the core Yoruba states (Oyo, Ogun, Osun, Ekiti and Ondo) and all other states in Nigeria especially for the treatment of cancer cases in general. Ibadan, a metropolis, is also a cosmopolitan as the different ethnic groups in Nigeria find an easy abode here with freedom to express their culture and ethnicity. Thus, the patients seen in Ibadan form a microcosm of the ethnic groups in Nigeria. Nigeria has over 10 ethnic groups with over 250 dialects and languages but the major ethnic groups are usually referred to as the big 3 i.e., the Hausa, Yoruba and the Igbo (Ibo). Other ethnic groups include the Tiv, Jukun, Fulani, Efik, Ibibio, Ijaw, Kalabari, Urhobo, Edo etc.

Reports on CRC from teaching hospitals in these locations have consistently shown a lower incidence as compared to UCH Ibadan and this has stimulated curiosity in finding a plausible explanation.

Over the last 40 years, reports from studies in Ibadan [1],[2] have shown that the incidence of CRC has been increasing steadily from about 18 to 20 per year to current figures of over 60 patients per year. None of the earlier studies had stratified the incidence into ethnic groups. Looking at the studies from other parts of the country involving major and other ethnic groups, the figures obtained from Jos (now part of middle belt of Nigeria but initially part of north) averaged 2 per year in 1 study [3] and 22 cases per year in another study. [4] Sites from what is known as the core north (Hausa/Fulani) showed 12.5 cases per year in Kano, [5] 6 cases per year in Maiduguri [6] and 5 cases annually in Sokoto. [7] In the riverine area of Nigeria, usually described as south-south, reports from Port Harcourt, a major city, reveal rates of less than 2 patients per year in the most recent publication of CRC to emanate from there [8] while a previous publication showed rates of less than 4 patients per year. [9] Calabar, home to both Efik and Ibibio, also in south-south, showed figures of about 5 cases of CRC per year; [10] indeed in the report from the Calabar cancer registry covering the period from 2004 to 2009, the top 7 cancers did not include CRC. [11] The Ibo comprise the largest ethnic community in the former eastern Nigeria and a study of malignant disease of the colon, rectum and anus in this region showed a yearly return of 5 cases of CRC. [12] A similar rate was observed in Benin City, the capital of Edo state, where 106 cases were encountered over a period of 20 years. [13] It is apparent that as one moves eastward, southward and northward in Nigeria, the incidence of CRC diminishes with greater significance southward (south-south). The culture, diet and terrain are drastically different. If one agrees that diet has been implicated as a major factor in colorectal carcinogenesis, then it behooves one to look closer at what is consumed in the riverine areas of Nigeria as these could well be cancer-preventive diets. Cassava bolus taken with spicy stews prepared with plenty of palm oil, green vegetables and fish are commonly ingested in this region. Documentation abounds on the chemo-preventive properties of these dietary constituents; indeed a typical Nigerian diet has been found to be protective against colon cancer in experimental situations using Wistar rats. [14] Red chili pepper is a constant spice used in all Nigerian diets; Capsaicin (Trans-8-Methyl-N-Vanilyl-6-Nonenamide) is the pungent ingredient found in red pepper and it represses the growth of malignant cell lines by its ability to induce apoptosis. [15],[16] Palm oil, green vegetables and fish have also been well-documented to have cancer-protective properties. [17],[18],[19]

If, as been earlier established by migration studies that as one moves from an environment of low CRC incidence to one with a high incidence, he/she or his/her offspring are at a higher risk of developing the disease, [20],[21] then, conversely, it stands to reason that leaving such high risk regions to those regions with very low risk of CRC will translate into reduced occurrence in those initially predisposed i.e., those with colonic polyps or ulcerative colitis. Now we have discovered that even in a region where CRC incidence is very low, there exists a micro-system within that system with even lower rates. This phenomenon of "lower incidence within a milieu of low incidence of CRC" is reportable and should be shared so that more research is done in this area to benefit others (especially in developed nations).

I will conclude with the opening passages of the introduction of a previous publication of mine: "The lower incidence of colon and rectal cancer in the native black African has continued to be a constant focus of research. Hopefully preventive factors may be discovered, which may help to reduce the significant health burden of patients who develop CRC in the western world." [1] This paper may well produce the impetus for a research project to closely study the living and eating habits of the people of the riverine areas of Nigeria with a view to prevent colon cancer.

 
   References Top

1.Irabor D, Adedeji OA. Colorectal cancer in Nigeria: 40 years on. A review. Eur J Cancer Care 2009;18:110-5.  Back to cited text no. 1
[PUBMED]    
2.Irabor DO, Arowolo A, Afolabi AA. Colon and rectal cancer in Ibadan, Nigeria: An update. Colorectal Dis 2010 Jul;12(7 Online):e43-9. Epub 2009 Apr 27.  Back to cited text no. 2
    
3.Sule AZ, Ajibade A. Adult large bowel obstruction: A review of clinical experience. Ann Afr Med 2011;10:45-50.  Back to cited text no. 3
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4.Mandong BM, Madaki AK, Mannaseh AN. Malignant diseases in Jos: A follow up. Ann Afr Med 2003;2:49-53.  Back to cited text no. 4
    
5.Edino ST, Mohammed AZ, Ochicha O. Characteristics of colorectal cancer in Kano, Nigeria: An analysis of 50 cases. Niger J Med 2005;14:161-6.  Back to cited text no. 5
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6.Yawe KT, Bakari AA, Pindiga UH, Mayun AA. Clinicopathological pattern and challenges in the management of colorectal cancer in sub-Saharan Africa. J Chinese Clin Med 2007;2:688-95.  Back to cited text no. 6
    
7.Mbah N. Hospital frequency of large bowel cancer: Factors thought to influence outcome. Niger J Clin Pract 2009;12:37-41.  Back to cited text no. 7
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8.Adotey JM, Jebbin NJ, Jebbin NJ. Colorectal cancer in Port Harcourt. Port Harcourt Med J 2008;2:198-203.  Back to cited text no. 8
    
9.Seleye-Fubara D, Gbobo I. Pathological study of colorectal cancer in adults Nigerians: A study of 45 cases. Niger J Med 2005;14:167-72.  Back to cited text no. 9
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10.Essiet A, Iwatt AR. Surgical management of large bowel cancer 1983-1988, University of Calabar Teaching Hospital audit. Centr Afr J Med 1994;40:8-13.  Back to cited text no. 10
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11.Calabar cancer registry. http://calcanreg.org/index.htm. Accessed 15 February 2012.  Back to cited text no. 11
    
12.Nwafo DC, Ojukwu JO. Malignant disease of the colon, rectum, and anus in Nigerian Igbos. Ann R Coll Surg Engl 1980;62:133-5.  Back to cited text no. 12
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13.Eze GI, Igbe AP, Obaseki DE, Akhiwu WO, Aligbe JU, Akang EEU. Presentation of colorectal cancers in Benin-City, Nigeria. Sahel Med J 2010;13:24-8.  Back to cited text no. 13
    
14.Osagie A, Eriyamrenu G, Prohp TP. Effect of a Nigerian type diet on indices of cell proliferation. Pakistan J Nutr 2008;7:262-5.  Back to cited text no. 14
    
15.Oyagbemi AA, Saba AB, Azeez OI. Capsaicin: A novel chemopreventive molecule and its underlying molecular mechanisms of action. Indian J Cancer 2010;47:53-8.  Back to cited text no. 15
    
16.Surh YJ. More than spice: Capsaicin in hot chilli peppers make tumor cells commit suicide. J Natl Cancer Inst 2002;94:1263-5.  Back to cited text no. 16
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17.Norat T, Riboli E. Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence. Eur J Clin Nutr 2003;57:1-17.   Back to cited text no. 17
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18.Wu M, Harvey KA, Ruzmetov N, Welch ZR, Sech L, Jackson K, et al. Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway. Int J Cancer 2005;117:340-8.  Back to cited text no. 18
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19.Oboh G. Antioxidant properties of some commonly consumed and under-utilized tropical legumes. Eur Food Res Technol 2006;224:61-5.  Back to cited text no. 19
    
20.Burkitt DP. Epidemiology of cancer of the colon and rectum. Cancer 1971;28:3-13.  Back to cited text no. 20
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21.Irabor DO. Colorectal carcinoma: Why is there a lower incidence in Nigerians when compared to Caucasians? J Cancer Epidemiol 2011;2011:675154. Epub 2011 Dec 29.  Back to cited text no. 21
    


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