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ORIGINAL ARTICLE
Year : 2014  |  Volume : 8  |  Issue : 1  |  Page : 32-36

Drug use pattern in sickle cell disease in a hematology unit of a teaching hospital in North-Western Nigeria


1 Department of Pharmacology and Therapeutics, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
2 Department of Pharmacology and Toxicology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
3 Department of Heamatology and Blood Transfusion, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria

Correspondence Address:
Iyabo Mobolawa Adebisi
Department of Pharmacology and Toxicology, Usmanu Danfodiyo University, Sokoto
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0331-3131.141027

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Background: Sickle cell disease (SCD) is an important public health problem in Nigeria, with a prevalence of about 20/1000 births, and with up to 24% of the general population carrying the trait. Globally, drugs account for about 60% of nonpersonnel cost of healthcare and about 50% of medications are presumed to be inappropriately prescribed, dispensed, or sold. This leads in part to increased cost of healthcare and emergence of drug resistance. Aim: The aim of the study was to assess the drug prescribing pattern in the management of SCD patients in a hematology unit of Usmanu Danfodiyo University Teaching Hospital in Sokoto, North-West Nigeria; and assess conformity to World Health Organization (WHO) specification. Materials and Methods: This was a cross-sectional retrospective study involving the review of 272 prescriptions from the case notes of SCD patients seen in the hematology clinic of Usmanu Danfodiyo University Teaching Hospital, Sokoto, a Tertiary Health Care Center in North-West Nigeria from June 2009 to July 2011. Data were collected from case notes of patients and were analyzed using descriptive statistics. Result: The mean age of SCD patients was 19.6 ± 4.5 years and 54.4% of the patients were male. A total of 1230 drugs was prescribed with an average of 4.5 drugs per prescription. Analgesics, antimalarials, vitamins, and antibiotics, accounted for 30.1%, 28.7%, 23.1%, and 8.7%, of the total prescriptions, respectively. Of the analgesics prescribed, acetaminophen accounted for 24.8%, nonsteroidal anti-inflammatory drugs (32.2%), and narcotics 43%. Artemisilin-based combination therapy was used in the management of malaria, and 73% of SCD patients had prophylactic antimalarial (proguanil). Penicillins accounted for over 60% of antibiotics used. Conclusion: Drug prescription in SCD patients is high, and thus it is recommended that WHO/International Network on Rational Drug Use standard and core prescribing indicators be adhered to.


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