Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 182
Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Advertise | Login 
     
ORIGINAL ARTICLE
Year : 2014  |  Volume : 8  |  Issue : 1  |  Page : 4-7

Short term heart rate variability for early assessment of autonomic neuropathy in patients with type 2 diabetes mellitus: A comparative cross-sectional study


1 Department of Physiology, SDM Medical College, Dharwad, Karnataka, India
2 Department of Medicine, SDM Medical College, Dharwad, Karnataka, India

Correspondence Address:
Anupama Deepak
Department of Physiology, SDM College of Medical Sciences and Hospital, Manjushree Nagar, Sattur, Dharwad, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0331-3131.141021

Rights and Permissions

Background: Cardiovascular autonomic diabetic neuropathy (CADN) is an important diabetes-associated complication. Reduced heart rate variation is the earliest indicator of CADN. Aims: The aim was to study the prospect of using short term heart rate variability (HRV) analysis for early diagnosis of CADN. Settings and Design: The type of this study was hospital-based comparative cross-sectional study. Materials and Methods: A total of 30 asymptomatic, type 2 diabetic male patients with duration of diabetes of 1-5 years with random blood sugar ≥200 mg/dl (11.1 mmol/L) or fasting blood sugar ≥126 mg/dl (7 mmol/L) in the age group of 30-65 years were selected as subjects. Thirty age and sex matched healthy nondiabetics were selected as controls. HRV analysis was performed using electrocardiogram recorded in lead II, at rest, in the supine position for 5 min. Results: Total power, low frequency power, high frequency power, standard deviation of all R-R intervals, root mean square of successive RR-interval differences, number of intervals differing by >50 ms from adjacent interval (NN50), and percentage of NN50 (pNN50) were significantly less in diabetics when compared to nondiabetics (P < 0.05). Conclusion: Data from the study demonstrated that asymptomatic diabetics with <5 years history had already developed autonomic neuropathy. Short term analysis of HRV can be used as a valuable tool for early diagnosis of autonomic neuropathy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3376    
    Printed169    
    Emailed0    
    PDF Downloaded389    
    Comments [Add]    

Recommend this journal